New Findings of Reduced Thalamo-Frontal Connectivity in Individuals Diagnosed with Schizophrenia Accepted for Publication

Our manuscript entitled, ‘Structural thalamo-frontal hypoconnectivity is related to oculomotor corollary discharge dysfunction in schizophrenia,’ was accepted at the Journal of Neuroscience. In this paper, we show that people diagnosed with schizophrenia have reduced structural connectivity in a specific brain pathway found to transmit sensorimotor prediction signals in nonhuman primates. Such reduced connectivity was associated with behavioral evidence for impaired sensorimotor predictions and psychotic symptoms. These findings have implications for understanding the mechanisms of schizophrenia and their altered sense of agency. A link to the full article will be provided once it becomes available.


MSU Clinical Neuroscience Lab